Are You “Double-Jointed”? A Simple Look at Hypermobility and the Brain–Body Connection

If you’ve ever bent your thumb back to your forearm or amazed people with your flexibility, you might be hypermobile (often called “double-jointed”). This simply means your joints move beyond the typical range.

For many people, this is completely harmless. But for others, it can be part of a broader pattern of physical and neurological symptoms.

What Is Hypermobility?

Hypermobility means your joints are more flexible than average.

Sometimes, it can be linked to Joint Hypermobility Syndrome (JHS), which may include:

  • Joint pain or frequent injuries
  • Fatigue
  • Digestive issues
  • General body sensitivity

In some cases, it can also be associated with genetic connective tissue conditions like Ehlers-Danlos Syndrome (EDS).

The Link to ADHD and Autism

Research shows a strong connection between hypermobility and neurodivergence, including ADHD and autism.

In fact, neurodivergent individuals may be up to four times more likely to be hypermobile.

Many people also experience symptoms related to the nervous system, such as:

  • Dizziness or lightheadedness
  • Rapid heart rate
  • Fatigue
  • Gut issues

This is often related to autonomic dysfunction, where the body has trouble regulating automatic processes like heart rate and digestion.

Why This Matters

For years, clinicians noticed that people with ADHD and autism often had more:

  • Chronic pain
  • Migraines
  • Digestive issues
  • Anxiety

We’re now beginning to understand that hypermobility may help connect these dots.

What the Research Shows

Research led by Dr. Jessica Eccles suggests there may be differences in how the brain processes pain and anxiety in people with hypermobility.

Her work points to changes in areas like the amygdala, along with disruptions in the nervous system—helping explain symptoms like fatigue, fainting, and heightened anxiety.

Spotlight: Dr. Jessica Eccles

In the spirit of Women’s History Month, it’s worth highlighting Dr. Jessica Eccles, a leading neurodevelopmental psychiatrist and researcher in this space.

Dr. Eccles’ work focuses on the connection between neurodivergence, connective tissue differences, and the nervous system. She has played a key role in bringing attention to how physical symptoms—like pain, fatigue, and autonomic dysfunction—intersect with ADHD and autism.

She’s also an engaging public educator, helping translate complex research into accessible, practical insights for both clinicians and patients.

If you’d like to learn more about her work:

Final Thoughts

Hypermobility isn’t just about being flexible—it can reflect a deeper brain–body connection.

If you recognize these patterns in yourself or your patients, it can be a helpful starting point for understanding symptoms more holistically—and finding the right support.

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